Chicken Little comes home to roost

Zoo chicken roostingTwo years ago I wrote a blog post expressing amusement at Altmetric’s top papers for 2013. Now that Altmetric is rating a paper of mine #5 of 13,240 outputs (from the journal publisher and as of time of writing), it is clearly time for me revisit my position on Altmetric. Surely, anything that ranks my collaborators and me that highly must be on to something? Altmetric is software that collects references in the news media, blogs and on twitter, to a research paper, and then both provides links to them, and ranks the paper.

More

The right tool for the job

I almost titled this post Daily Mail celebrates work of immigrants shocker but as they have written a pretty accurate article on work I am part of, that would be a bit ungrateful. Yesterday a paper came out in Physical Review Letters that I am really rather proud of, although I made only a small contribution to it. Most of the credit should go to Andrea Fortini, who discovered the effect the paper describes, and to Nacho Martin-Fabiani and Joe Keddie who did the experiments to show that it works in the real world too. Andrea found the effect in computer simulations. We also had help from collaborators in Lyon who made the particles Nacho used.

More

The economics of life, death and weekend working

The Health Secretary Jeremy Hunt has been going round saying* “At the moment, for example, if you have a stroke at the weekend you are 20% more likely to die. That cannot be right, and that is something every doctor wants to sort out as well.”. This is a rather alarming way of saying that 11.1% of those admitted on a weekday because they have had a stroke are dead within 30 days, whereas 12.9% of those admitted on a weekend die within 30 days. This is from work of Roberts and coworkers.

More

Tiny tiny origami

DNA Origami TriangularMy Christmas reading has included a PhD* thesis, I am external examiner for a student at Oxford, and the viva is mid-January. The thesis is on the computer simulations of a model of DNA. The simulations are of what is called DNA origami. Origami is of course folding up a sheet of paper in a precise way, to make a paper plane, paper flower, etc.

More

Interwoven networks of crystals

This is an animation of a rotating cubic box containing a few thousand molecules. It is from computer simulations by James Mithen, who postdoced with me. Most of the molecules are in one of two different crystals, the yellow ones are in a type of crystal called a face-centred cubic (fcc) crystal, while the green ones are in a different type of crystal called body-centred cubic (bcc). Both are crystals in the sense that the molecules are arranged in a regular lattice but the two lattices are different, for example, in the fcc crystal each molecule has 12 neighbours while in bcc each molecule has 8.

More

Jelly is bad for our nerves

My Christmas viewing has included (amongst the Strictly, Agatha Christie adaptation, etc) a webinar entitled Fluid Business: Could “Liquid”Protein Herald Neurodegeneration? The webinar is on droplet-like structures inside nerve cells that may be associated with some diseases that kill these nerve cells, such as Alzheimer’s, amyotrophic lateral sclerosis (ALS), etc. The webinar includes short talks by a number of scientists, including a presentation by Peter St George-Hyslop that is based on a very recent paper in Neuron. The report reports a lot of work by a small army of scientists on a protein called FUS. Some mutant variants of FUS are associated with the disease ALS.

More

Teaching till I drop, and now some chaos

grMost of my teaching is in the semester whose teaching weeks ended yesterday — it has been a bit crazy. I was more-or-less completely revising two of the three courses I was teaching, so I was a like a little hamster perpetually running on a hamster wheel of lecture and question sheet writing.

More

Many genes, simple models

cancer_fit
Next week is the last teaching week of this semester. I have been revising almost from scratch both of my second year courses, which at times has taken most of my waking moments. Most of my teaching is this semester, so I have been crazy busy. But I have had time to add a small new bit to my final-year biological physics course. This  is on the fact that many aspects of our bodies, and the diseases that afflict them, are controlled not by a single gene, but by many.

More

Creating a paper trail to prove an article is on the web

This post is a slight lament at good intentions turned bureaucratic drag. In what we must now call the good old days, the final stages of publishing a scientific paper were free of paperwork. You would just check the proofs of your article, then sit back and wait for it to appear, whereupon your coauthors and you could sit back and bask in a warm glow.

More