Membrane proteins and the Curse of Dimensionality


I am at a conference in Sorrento, Italy. My hotel room is described as having a ‘hill view’, and as you can see from this picture taken from my hotel room, the description is accurate. That is a genuine Italian hill. In Sorrento, I will be talking about my work on paint drying, but I have a bit of time before the conference sessions start. So, I am also working on a course I am teaching next month for the EU network on RAtionalising Membrane Protein crystallisation (RAMP).


A trip to Bordeaux to learn about very tiny plumbing

Microfluidic Chip iX-factoryI would to start this post by acknowledging how impressed I am with the style of the French guy who strode confidently onto Friday’s flight from Bordeaux to London wearing a large string of cloves of garlic draped around his neck. Some people just have natural style. As someone who does not, I am a bit envious. My PhD student and I were in Bordeaux as part of an EU research network (called RAMP) on crystallising proteins. There is a research lab in the suburbs of Bordeaux that is world leading at what is called microfluidics — essentially plumbing but instead of pipes centimetres across that move litres, microfluidics has pipes that are less than 1 millimetre wide and move as little as billionth of a litre, a nanolitre. The channels above in the microfluidic device shown above are only 0.15 mm wide.


Self-assembly pope and self-assembling proteins in soap

Over the Christmas period I have been trying out a few beers, including Brewdog’s weirdly named Self Assembly Pope. This beer is a porter, with some cocoa, coconut and vanilla added to spice it up. It is a pretty good porter, although I am not a big fan of coconut, on its own or in beer, and so probably will not be coming back to it*. What I will be doing in 2017 is working on getting membrane proteins to self-assemble into as large and as regular crystals as possible. This is part of an EU-wide network on membrane-protein crystallisation that will be starting in 2017. Membrane proteins are proteins that live in back-to-back layers of soapy molecules — which is what cell membranes are. Membrane proteins are important as many (by some measures a majority) of drugs target these proteins.